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OPHTHALMOLOGY TIMES EUROPE EDITORIAL ADVISORY BOARD
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AMD Clinicals
Increased intake of carotenoids and fish oil doesn't reduce AMD risk further
Increased oral supplementation of carotenoids (lutein and zeaxanthin) and omega-3 fatty acids, found in fish oil, does not reduce the risk of AMD progression further to the original AREDS formulation, claims the latest results of the Age-Related Eye Disease Study (AREDS2).
Laser confocal imaging useful for AMD

Scanning laser ophthalmoscopy with a lateral confocal aperture could highlight subclinical drusen and aid in the progression of monitoring in AMD patients, claims the latest paper in the British Journal of Ophthalmology.

Kaiser study results on ranibizumab and bevacizumab
A Kaiser Permanents Southern California study published in this month?s Ophthalmology, the journal of the American Academy of Ophthalmology, compares ranibizumab (Lucentis) and bevacizumab (Avastin) and found them to be equally effective in halting vision loss.
First ever sham-controlled study of radiation therapy for wet AMD initiated by Oraya Therapeutics
)? Oraya Therapeutics, Inc., announced today that enrollment is now underway for the first ever masked and sham-controlled study to demonstrate the efficacy and safety of radiation therapy for the treatment of wet age-related macular degeneration (AMD). The groundbreaking clinical trial is being conducted at seven European sites, and will include a minimum of 150 patients, with approximately one third of those receiving a sham exposure and the remainder receiving radiation dosing of either 16 or 24 Gray (GY).
Visudyne evaluation indicates positive results
Positive twelve-month primary analysis results from the Phase II RADICAL study (Reduced Fluence Visudyne Anti-VEGF-Dexamethasone In Combination for AMD Lesions) in patients with wet age-related macular degeneration (wet AMD) have been announced by QLT Inc.
Gene genie collaboration
A new collaboration between Oxford BioMedica and Sanofi-Aventis is to develop and commercialise gene therapy treatments for retinal degenerative diseases such as Stargardt disease, the form of early-onset macular degeneration and Usher syndrome, a relatively rare genetic disease where sufferers are born deaf and lose vision within the first 10 years of life.
The IOL-VIP system: restoring sight to AMD patients
Dr José Luis Menezo looks at improving the visual acuity of patients with age-related macular degeneration (AMD) using an IOL-Vip system.
Treating wet AMD with radiation
A single procedure may be as effective as repeated anti-VEGF injections claims Timothy L. Jackson.
Eye drops: a breakthrough in dry AMD treatment?
Paul Sternberg assesses the new approaches and exciting pipeline of potential dry AMD treatments.
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AMD news
Increased intake of carotenoids and fish oil doesn't reduce AMD risk further
Increased oral supplementation of carotenoids (lutein and zeaxanthin) and omega-3 fatty acids, found in fish oil, does not reduce the risk of AMD progression further to the original AREDS formulation, claims the latest results of the Age-Related Eye Disease Study (AREDS2).
Laser confocal imaging useful for AMD

Scanning laser ophthalmoscopy with a lateral confocal aperture could highlight subclinical drusen and aid in the progression of monitoring in AMD patients, claims the latest paper in the British Journal of Ophthalmology.

Macular translocation is still effective after five years
It is possible for AMD patients to maintain BCVA for fives years after macular translocation surgery..
Cases of peripheral yellow corneal rings of AMD revealed
Peripheral yellow corneal rings are more common in age-related macular degeneration (AMD).
Implantable telescope finally gets FDA approval
VisionCare&#;s implantable telescope for end-stage AMD has finally been given FDA approval. The device, discussed in depth in Ophthalmology Times Europe July 2007, was given CE approval three years ago but has subsequently been undergoing rigorous clinical trials in the United States.
IRay stereotactic radiotherapy system gets European CE mark
Oraya Therapeutics has been granted the CE mark for its IRay system, which its researchers say can deliver low-energy X-rays to treat wet AMD.
First ever sham-controlled study of radiation therapy for wet AMD initiated by Oraya Therapeutics
)? Oraya Therapeutics, Inc., announced today that enrollment is now underway for the first ever masked and sham-controlled study to demonstrate the efficacy and safety of radiation therapy for the treatment of wet age-related macular degeneration (AMD). The groundbreaking clinical trial is being conducted at seven European sites, and will include a minimum of 150 patients, with approximately one third of those receiving a sham exposure and the remainder receiving radiation dosing of either 16 or 24 Gray (GY).
Cancer drug no different in effectiveness as gold standard treatment for macular degeneration
Investigators from Boston University School of Medicine (BUSM) and the VA Boston Healthcare System have shown, at 6 months in a small group of patients, that there is no difference in efficacy between Bevacizumab (Avastin) and Ranibizumab (Lucentis) for the treatment of age-related macular degeneration (AMD).
Early AMD associated with coronary heart disease
The results of a study published in the July issue of Ophthalmology has discovered that people in the early stages of age-related macular degeneration (AMD) are at a higher risk of developing coronary heart disease (CHD), offering further support to the theory that AMD is associated with underlying systemic vascular disease.
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CatRef clinical
Macular thickness increases after cataract surgery
Macular thickness significantly increases up to six months after uncomplicated cataract surgery, according to an investigation featured in the journal Eye.
RDO patient pathway improves operative rates in cataracts
Operative rates for cataract surgery are higher for the refined direct optometrist (RDO) patient pathway, compared to the GP pathway, reveals a recent investigation in the UK.
Piggyback toric IOL effective for astigmatism
Implanting a customized primary or a secondary piggyback toric IOL post-penetrating keratoplasty (PK) is effective for astigmatism, claims a paper in Eye.
Multifocal diffractive add-on IOL suitable alternative
Multifocal diffractive add-on IOL is a suitable alternative to standard multifocal IOLs for sulcus fixation.
Limiting IOP rise in laser cataract procedures
Catalys Precision Laser System features particularly beneficial for compromised cataract patients
Surgical compensation of presbyopia with a corneal inlay implantation
Two-year results revealed of reading performance and patient satisfaction with KAMRA
Caution needed for full correction in low astigmatism

Caution should be used when considering full astigmatic correction for manifest cylinder of 0.5 D or less in myopic patients, according to the latest investigation in the Journal of Cataract and Refractive Surgery.

ECD not linked to CCT in keratoconus

Corneal endothelial cell density (ECD) changes are independent from central corneal thickness (CCT) in keratoconus patients, states a recent paper.

Loteprednol etabonate controls inflammation and IOP

Loteprednol etabonate controls inflammation and reduces IOP fluctuation after cataract surgery, according to a recent study.

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CatRef features
Mastering corneal inlays
Optimum centration of corneal inlays is vital for successful presbyopia correction
Femto phaco vs traditional phaco
First clinical results in the Eye Hospital Bellevue Kiel, Germany
Premium IOL options
For compromised, and potentially compromised eyes.
Multifocal IOL a successful option
FDA results and personal experience demonstrate very high satisfaction with lens
A new method for easier enclavation of iris-claw IOLs
The VacuFix technique has been introduced to fix the Artisan and Artiflex IOLs in a fast, precise and reproducible way.
Do personality characteristics impact multifocal IOL patient satisfaction
First answers from the Happy Patient Project
Visual performance of a new multifocal diffractive IOL
Comparative study shows excellent intermediate vision results, high levels of spectacle independence and minimal photic phenoma at night.
Technique enables surgical success in IFIS
Combining 1.8 mm C-MICS and phacoemulsification system enables safe and effective cataract surgery in eyes with intraoperative floppy iris syndrome.
Smaller incisions attract larger audience
Continuing development within the industry and more evidence demonstrating the advantages of MICS is further increasing interest into the surgical technique.
 MORE ARTICLES

CatRef news
RDO patient pathway improves operative rates in cataracts
Operative rates for cataract surgery are higher for the refined direct optometrist (RDO) patient pathway, compared to the GP pathway, reveals a recent investigation in the UK.
Piggyback toric IOL effective for astigmatism
Implanting a customized primary or a secondary piggyback toric IOL post-penetrating keratoplasty (PK) is effective for astigmatism, claims a paper in Eye.
Excellent visual outcomes in cataract surgery
Cataract surgery produces excellent visual outcomes, with 61.3% of patients achieving a corrected distance visual acuity of 20/20 or better, according to a database study in the Journal of Cataract and Refractive Surgery.
FS-laer assisted intrastomal arcuate keratotomy a success
Intrastromal arcuate keratotomy performed with a femtosecond (FS) laser has an excellent safety profile, rapid recovery and stability of vision, claims a new paper.
Multifocal diffractive add-on IOL suitable alternative
Multifocal diffractive add-on IOL is a suitable alternative to standard multifocal IOLs for sulcus fixation.
Multicomponent IOL provides excellent vision
Multicomponent IOL implantation is safe, easy and provides excellent vision, according to a recent case series.
Risk factors for esotropia reoperation revealed
Underaction of the lateral rectus muscle could be a risk factor for reoperation of congenital esostropia, claims an investigation in the Journal of Pediatric Ophthalmology and Strabismus.
Caution needed for full correction in low astigmatism

Caution should be used when considering full astigmatic correction for manifest cylinder of 0.5 D or less in myopic patients, according to the latest investigation in the Journal of Cataract and Refractive Surgery.

ECD not linked to CCT in keratoconus

Corneal endothelial cell density (ECD) changes are independent from central corneal thickness (CCT) in keratoconus patients, states a recent paper.

 MORE ARTICLES

Cataract Clinical
Macular thickness increases after cataract surgery
Macular thickness significantly increases up to six months after uncomplicated cataract surgery, according to an investigation featured in the journal Eye.
RDO patient pathway improves operative rates in cataracts
Operative rates for cataract surgery are higher for the refined direct optometrist (RDO) patient pathway, compared to the GP pathway, reveals a recent investigation in the UK.
ECD not linked to CCT in keratoconus

Corneal endothelial cell density (ECD) changes are independent from central corneal thickness (CCT) in keratoconus patients, states a recent paper.

Multiple micro-bypass stents lower IOP
Multiple micro-bypass stents with concurrent cataract surgery lowers IOP to less than 15 mmHg in patients with open-angle glaucoma (OAG) and cataract.
Safety first: pIOL is effective for myopic astigmatism
Implantation of the Artiflex toric iris-fixated phakic IOL is effective, predictable and safe for the correction of myopic astigmatism.
Adjunctive safety tool proves valuable
Mapping epithelial thickness in patients with abnormal topography may rule out keratoconus
Evaluation of the change in tear osmolarity after using different eye drops
Left untreated, dry eye can cause many problems in the post operative period. As many as 33 million adults may be undiagnosed
Toric IOLs in cataract surgery
What guides a surgeon's choise?
Presbyopia correction through monovision
Is monovision in your armamentarium?
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Cataract News
Macular thickness increases after cataract surgery
Macular thickness significantly increases up to six months after uncomplicated cataract surgery, according to an investigation featured in the journal Eye.
RDO patient pathway improves operative rates in cataracts
Operative rates for cataract surgery are higher for the refined direct optometrist (RDO) patient pathway, compared to the GP pathway, reveals a recent investigation in the UK.
Excellent visual outcomes in cataract surgery
Cataract surgery produces excellent visual outcomes, with 61.3% of patients achieving a corrected distance visual acuity of 20/20 or better, according to a database study in the Journal of Cataract and Refractive Surgery.
ECD not linked to CCT in keratoconus

Corneal endothelial cell density (ECD) changes are independent from central corneal thickness (CCT) in keratoconus patients, states a recent paper.

Loteprednol etabonate controls inflammation and IOP

Loteprednol etabonate controls inflammation and reduces IOP fluctuation after cataract surgery, according to a recent study.

Optos urges skiers to consider eye health

Optos is urging skiers to ensure they take care of their eyesight while on the slopes this winter, according to their latest press release.

Gel cuts inflammation and pain

Loteprednol etabonate gel 0.5% is efficacious and safe for treating postoperative inflammation and pain caused by cataract surgery, claims a recent report.

Povidone-iodine and antibiotics effective for cataract surgery
Preoperative povidone-iodine and postoperative intracameral antibiotic injections are recommended for endophthalmitis prophylaxis, claims a recent paper.
MICS IOL modification does not affect PCO
Modifying a MICS IOL from a 3-piece to a 1-piece haptic design does not cause any significant changes in PCO amount.
 MORE ARTICLES

Cornea
Corneal degeneration is more common in white women
Peripheral hypertrophic subepithelial corneal degeneration is an uncommon disorder that occurs mostly in white women with a distinct phenotype, claims a study in the journal Ophthalmology.
Visual acuity poorly linked to GT after DSAEK
Visual acuity poorly correlates to graft thickness (GT) in patients who underwent descemet stripping automated endothelial keratoplasty (DSAEK), states a paper in the journal Cornea.
KLAL significantly affected by adverse events
Keratolimbal allograft (KLAL) transplantation is affected by adverse events including immunologic rejections, chronic ocular surface exposure and graft-related complications, according to a study featured in Cornea.
FS-laer assisted intrastomal arcuate keratotomy a success
Intrastromal arcuate keratotomy performed with a femtosecond (FS) laser has an excellent safety profile, rapid recovery and stability of vision, claims a new paper.
Big bubble size can be safely increased

Undersized big-bubbles for DALK can safely be increased using blunt dissection for white-margin bubbles and ophthalmic viscosurgical device injection for clear-margin bubbles.

Mushroom configuration can perform corneal cuts
Femtosecond laser (FSL)-assisted mushroom configuration deep anterior lamellar keratoplasty (DALK) is reliable and reproducible, stated a recent noncomparative case series.
Eye viscosity increases with age
According to a paper published in Clinical and Experimental Ophthalmology, loss of energy due to elastic hysteresis positively correlates with age, leading to the belief that eye viscosity increases with age.

ICRS depth less than expected using OCT

Depth of intrastromal corneal ring segments (ICRS) is less than expected in myopic patients when measured by OCT, claims a recent paper.

OSST should be closely monitored for rejection
Ocular surface stem cell transplantation (OSST) patients should be closely monitored for rejection and compliance with immunosuppression.
 MORE ARTICLES

Dry Eye
New financing round for dry eye portfolio
Novaliq has secured €13.9 million in a fifth round of financing for a dry eye portfolio.
High index of suspicion required for SS
A high index of suspicion is required for underlying Sjögren's syndrome (SS) in patients with clinically significant aqueous-deficient dry eye.
The ideal drop through the eyes of doctors and patients
Five steps and the criteria for success, as seen through the eyes of patients and their doctors...
Contact induced dry eye
Understanding the problems of contact lens induced dry eye
Tear cytokine and chemokine analysis and clinical correlations in evaporative-type dry eye disease
In a sample of moderate evaporative-type dry eye disease patients Enriquez-de-Salamanca et al., elevated five inflammatory molecules. Fracktalkine was demonstrated to be present and elevated in tears in human DED.
Cyclosporine helps prevent progression of dry eye
A recent study showed that moderate to sever dry eye disease can be best treated with anti-inflammatory medications such as topical cyclosporine. According to one ophthalmologist, cyclosporine can significantly limit progression of dry eye disease and should be considered a 'go-to' therapy for this patient population.
Out with the old and in with the new
A comparison of an older nanoliter osometer and a newer osometer shows that both devices are effective in measuring tear osmolarity and produce comparable measurements.
Insert improves symptoms and quality of life for patients with dry eye
The use of hydroxypropyl cellulose can significantly improve the symptoms of dry eye, resulting in increased quality of life.
New options in treating lid wiper epitheliopathy
An oil-in-water and a corticosteroid were both effective in eliminating the signs and symptoms of lid wiper epitheliopathy after a 1-month active treatment phase in a recent study. Improvement was effectively maintained with the emollient eye drops in all patients over a 12-month period.
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ESCRS 2008 news
Moria introduces single-use cataract instruments
The "One" range of single-use ophthalmic instruments has been introduced by Moria. The range comprises instruments commonly used during cataract surgery; instruments are available individually, or as part of a custom pack.
It's all changing at Zeiss
Recent acquisitions, division restructuring, and management changes prove that Carl Zeiss Meditec is very much committed to change. Ophthalmology Times Europe spoke with CEO, Dr Michael Kaschke about the challenges that he faces in an ever evolving market.
Femtosecond benefits in corneal procedures
Dr Rudi Nujits, presented new research on femtosecond laser assisted Descemet Stripping Endothelial Keratoplasty (FS-DSEK) at a session on the femtosecond laser and therapeutic corneal surgery.
Volk launches high resolution wide field lens
Volk Optical has launched the H-R Wide Field Laser Lens, a pan-retinal lens intended for diagnosis and PRP laser treatment.
Seiler vs Holladay: the presbyopia debate
The search for a presbyopic treatment that is universally effective and universally applicable is viewed in the industry and the profession as the holy grail because of the number of people in the presbyopic age group today.
Oertli proud of new 1.6 mm tip
Oertli proudly showcased their new product that enables coaxial microincision cataract surgery through 1.6 mm: the CO-MICS 2 tip is fully compatible with the firm's existing OS3, SwissTech and CataRhex platforms.
Femtosecond to fully replace microkeratome
The age of microkeratomes is coming to an end as femtosecond lasers come of age. That's the chief conclusion drawn by Dr Gunther Grabner, professor of ophthalmology at the Paracelsus University of Salzburg, in a survey on the advantages and limitations of femtosecond lasers.
Dry eye diagnostic coming to a clinic near you
OcuSense, makers of the innovative TearLab Osmolarity System for the diagnosis of dry eye, announced the signing of multi-year agreements with four distributors in five EU countries, for the exclusive distribution of the TearLab system.
Haag-Streit showcases comprehensive new optical biometer
Haag-Streit has taken the opportunity of the ESCRS meeting to unveil its innovative non-contact optical biometer, the LENSTAR LS900.
 MORE ARTICLES

From the Editor
Berlin Beckons
Join OTE in booth BL10 at this year's ESCRS congress
Thank you!
Although we have always received a steady stream of feedback from readers, contributors and industry, never have we been bombarded by so many compliments in such a short space of time as at two recent conferences.
What do you want to see in OTE in 2009?
Fill in OTE's online readership survey for the chance to win €500 Marriott hotel vouchers.
The industry's evolving, so are we
Sometimes I sit back and think about how this magazine has evolved over the years and, on a more regular basis, I think about where we can go from here.
Micro innovations
In technological terms, when a word is prefixed by 'micro' you come to expect that word to signify some form of technological innovation or advance. In ophthalmology, the word 'microincision' represents significant advancement, particularly in the fields of cataract and vitreoretinal surgery.
World Glaucoma Day 2008: uniting to make a difference
The lack of public knowledge about glaucoma surprises me. Although pretty much everybody has heard of it, little is generally known other than the fact that it affects the eye.
LASIK: some still in the dark
I recently attended a party where I was drawn into a conversation by some people who had one thing in common – LASIK. Somebody amongst the group had undergone the procedure six years ago (incidentally, that was my sister) whilst another underwent wavefront-guided LASIK just weeks prior. Each of the four people had a story to tell about their experience with the procedure but, overall, each claimed they were happy with the end result.
Tempted by a free trip for two?
Tempted?
We invite you to have your say
When we launched Ophthalmology Times Europe (OTE) two years ago, our aim was always to provide a forum for ophthalmologists to communicate their knowledge, discoveries, experience and opinions. This aim has not changed. However, with the industry evolving at such a dramatic rate, it is difficult to convey the views and opinions of everyone who wants to be heard in our print publication. Help is at hand.
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Glaucoma clinical
Diverse factors affect management
Ever-widening knowledge base proves that there's more to it than controlling IOPs.
Physician education boosts interaction
Strategy can improve patient compliance with glaucoma medication regimens.
Compliance & cost concerns
What's the role for SLT?
Continuous monitoring of changes of intraocular pressure — a self-trial
Monitoring IOP pressure during sleeping hours, two doctors test it out for themselves
Switching from preserved to preservative-free prostaglandin
Investigating the tolerability and IOP reduction effect of switching from latanoprost to tafluprost in patients exhibiting ocular surface side effects
Pressure-independent factors in glaucoma
Glaucoma is a final pathway of amny different disorders that can lead to a common pattern of optic nerve and visual field damage
Trab-shunt debate
Clinicians pose several arguments for trabeculectomy and tube-shunt surgery
Device aids glaucoma testing
FD-OCT adds accuracy to diagnostic assessment with measurement of GCC
First choice for glaucoma
Medical therapies are effective, but expensive too
 MORE ARTICLES

Glaucoma news
Axial length affects RNFL thickness profiles

Axial length/refractive status affects the peripapillary retinal nerve fibre layer (RNFL) thickness profile in eyes measured by RTVue OCT.

Rudin Glaucoma Prize winner announced

Dr Daniel Stamer has been awarded the prestigious Lewis Rudin Glaucoma Prize 2012.

Anti-glaucoma eye drops linked to meibomian gland changes
The long-term use of anti-glaucoma eye drops is linked to changes in meibomian gland morphology and function.
Legal fitness to drive influenced by BEMD

Better eye mean deviation (BEMD) strongly affects a patient's legal fitness to drive (LFTD), according to recently published data.

ICS use maintains RNFL rate
Intranasal corticosteroids (ICS) maintain retinal nerve fibre layer (RNFL) thickness and optic nerve cup to disc ratio among patients with glaucoma or glaucoma suspect.
Contact lens sensor provides 24-hour IOP monitoring
A contact lens sensor is able to provide continuous 24-hour IOP monitoring for the management of glaucoma.
Statins reduce OAG risk in hyperlipidemia
The use of statins has been linked to a significant decrease in open-angle glaucoma (OAG) risk in patients with hyperlipidemia.
Caffeine increases IOP and OPP in POAG
Consuming one cup of caffeinated coffee statistically increases IOP and ocular perfusion pressure (OPP) in primary open-angle glaucoma (POAG) patients.
Glaucomatous damage detected with SD-OCT
SD-OCT imaging and retinal nerve fibre layer (RNFL) assessment successfully detects pre-perimetric glaucomatous damage.
 MORE ARTICLES

IOL articles
Multifocal IOL a successful option
FDA results and personal experience demonstrate very high satisfaction with lens
Do personality characteristics impact multifocal IOL patient satisfaction
First answers from the Happy Patient Project
Premium IOL options
For compromised, and potentially compromised eyes.
Visual performance of a new multifocal diffractive IOL
Comparative study shows excellent intermediate vision results, high levels of spectacle independence and minimal photic phenoma at night.
Bausch & Lomb Introduces the Crystalens Aspheric Optic (AO) Lens
Crystalens AO is the first aberration-free accommodating IOL
Novel scleral lens proves cost-effective
In the December issue of the American Journal of Ophthalmology Brandeis University researchers published a paper about the highly precise scleral lens, to treat severe cornea or ocular surface disease, the Boston Ocular Surface Prosthesis (BOS-P).
IOL evolution for presbyopia
“As we move into the 21st century the role of the IOL will evolve allowing better outcomes in cataract surgery and find new roles in surgery to improve vision such as through the treatment of presbyopia.”
Partnering multifocal IOLs with LASIK to achieve perfect vision
Without performing LASIK, 85-90% of [multifocal IOL] patients may achieve spectacle independence. However, with LASIK success rates are about 99%
IOL implantation in children
The desired refractive outcome is approximately 2 D by age two and 1 to 2 D by age three, reflecting the fact that the majority of growth of the eye has occurred by this age
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IOL features
Review of the year 2010
A review of the year in cataract & refractive, retina and glaucoma. Shows three industry experts view on their highs of the year and the changes they've experienced as well as what the future holds for 2011
Two does become one
We report on the first cataract and refractive femtosecond laser
Mixing multifocal IOLs associated with high patient satisfaction
Using both diffractive and refractive IOLs in fellow eyes can result in excellent outcomes
IOL delivers on visual quality, acuity
Aberration-free optic
60 years of pioneering IOL innovation
Rayner Intraocular Lens Limited, has marked a milestone with a celebration to honour the 60th anniversary of the implantation of the first intraocular lens (IOL) in a patient. The late Sir Harold Ridley implanted the first IOL on 29 November 1949 at St. Thomas Hospital in London. Due to the controversial nature of the surgery, this first surgery was conducted in almost total secrecy.
Novel scleral lens proves cost-effective
In the December issue of the American Journal of Ophthalmology Brandeis University researchers published a paper about the highly precise scleral lens, to treat severe cornea or ocular surface disease, the Boston Ocular Surface Prosthesis (BOS-P).
Multifocal IOLs
Have a closer look at some of the multifocal IOLs available in Europe.
Monofocal IOLs
Take a look at some of the Monofocal IOLs available in Europe.
Accommodating IOLs
Accommodating IOLs are making a splash in Europe - why don't you take a closer look at some of them?
 MORE ARTICLES

Infection & Inflammation
Point of care tear film test simplifies dry eye management
Diagnosing and managing dry eye patients can be challenging. Here Dr Philipp Steven looks at a new way of treating tear film osmolarity, the TearLab Osmolarity System, which he believes could dramatically simplify the process.
Clinical improvement in adenoviral conjunctivitis model
Foresight Biotherapeutics, Inc. has announced data from a pre-clinical study designed to assess the safety and efficacy of the topical administration of FST-100 in a highly regarded Ad5 NZW rabbit model of adenoviral conjunctivitis.
Novagali technologies allow greater drug access to the posterior of the eye
According to research analysts it is estimated that as little as five percent of a topically applied drug ever reaches the intraocular tissues due to drug loss as the result of tearing, lacrimal fluid-eye barriers, and blood-ocular barriers.
Liquid ocular bandage launched in Europe
BD OcuSeal Liquid Ocular Bandage, a fully synthetic protective barrier to be used for post-surgical, post-traumatic and non-traumatic ocular conditions, has been launched in Europe by BD Medical?Ophthalmic Systems.
Retisert implant in sympathetic ophthalmia
The fluocinolone acetonide (Retisert; Bausch & Lomb) surgical implant can prevent blindness in cases of sympathetic ophthalmia (SO), according to research at the University of Iowa, US.
Link between skin cancer and eye cancer
There is an association between uveal and a variety of skin melanomas, according to study results published in the March issue of Ophthalmology.
Uveitis study enters Phase IIa
ESBATech AG, a developer of antibody fragment therapeutics, has initiated a Phase IIa study in patients with acute anterior uveitis, designed to evaluate the safety, tolerability and clinical activity of topically applied ESBA105.
Causes of infectious scleritis
Fungus and microbial infection are the most common causes of infectious scleritis, according to study conclusions published in the February issue of Eye.
Anti-inflammatory enters Phase I/II
ESBA105, an anti-TNF alpha antibody fragment designed to reduce inflammation in patients undergoing cataract surgery, has begun a Phase Ib/IIa trial, according to an announcement from ESBATech AG, the antibody's developer.
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Interview
Open your mind to a new philosophy
Didier Ducournau talks about the development and growth of the EVRS and on his personal vision for vitreoretinal surgeons.
The Italian pioneers
Surgeons should not feel ashamed if they only manage to see a few patients, devotion to the patient and then to your practice is of paramount importance. Then, and only then, will you be doing your job well.
European Society of Ophthalmology: the first 50 years
Since its inception in 1956, the European Society of Ophthalmology (SOE) has grown from a small entity into a conglomerate of national ophthalmological societies from all 40 European countries, representing more than 40,000 European ophthalmologists. We speak with President Zdenek Gregor about the changing face of the society, the importance of collaboration and the way the society has adapted to an ever-evolving Europe.
Learning to work together
1991 witnessed the birth of the European Society of Cataract and Refractive Surgeons (ESCRS); a new kind of society aimed at unifying specialists and societies across a number of disciplines throughout the continent. Society President, Professor Marie José Tassignon talks to OTE about her vision for the future.
 MORE ARTICLES

Latest News
Macular thickness increases after cataract surgery
Macular thickness significantly increases up to six months after uncomplicated cataract surgery, according to an investigation featured in the journal Eye.
Corneal degeneration is more common in white women
Peripheral hypertrophic subepithelial corneal degeneration is an uncommon disorder that occurs mostly in white women with a distinct phenotype, claims a study in the journal Ophthalmology.
Increased intake of carotenoids and fish oil doesn't reduce AMD risk further
Increased oral supplementation of carotenoids (lutein and zeaxanthin) and omega-3 fatty acids, found in fish oil, does not reduce the risk of AMD progression further to the original AREDS formulation, claims the latest results of the Age-Related Eye Disease Study (AREDS2).
Visual acuity poorly linked to GT after DSAEK
Visual acuity poorly correlates to graft thickness (GT) in patients who underwent descemet stripping automated endothelial keratoplasty (DSAEK), states a paper in the journal Cornea.
RDO patient pathway improves operative rates in cataracts
Operative rates for cataract surgery are higher for the refined direct optometrist (RDO) patient pathway, compared to the GP pathway, reveals a recent investigation in the UK.
Stepladder technique successful for malignant glaucoma
Malignant glaucoma can be successfully managed using the stepladder technique, including timely and appropriate interventions, claims a paper in the journal Ophthalmology.
DME patient treated with Iluvien

Iluvien has been used to treat a diabetic macular oedema (DME) patient in the UK since the product became commercially available, it was revealed in a press release this week.

Combined scleral buckle and BGI is effective
Combined scleral buckle and Baerveldt glaucoma implantation (BGI) is effective for managing coexisting glaucoma and retinal detachment.
KLAL significantly affected by adverse events
Keratolimbal allograft (KLAL) transplantation is affected by adverse events including immunologic rejections, chronic ocular surface exposure and graft-related complications, according to a study featured in Cornea.
 MORE ARTICLES

Letters
Dear Editor
In answer to the question: "What specifically makes SLT different from ALT in its action?" we offer the following response:
An African expedition
I embarked on a memorable trip to Africa recently and, along with a wonderful team of skilled ophthalmologists and nurses, we set up two eye camps in Namibia and Zambia. Our mission was to study corneal thickness in native Africans so that we could, in the future, establish the relationship between corneal thickness and glaucoma in this population.
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Meeting Highlights
Highlights from AAO 2007
Read Ophthalmology Times' extensive coverage from the 2007 annual meeting in New Orleans, USA.
Highlights from the ESCRS Congress 2007
Read Ophthalmology Times Europe's extensive coverage from the 2007 annual meeting in Stockholm, Sweden.
IGS 2007 Meeting Highlights
Athens played host to the sixth annual International Glaucoma Society (IGS) congress, which ran from 28-31 March. Attended by more than 2,650 participants from around the world, the meeting earned the title of the most attended international glaucoma meeting ever held.
Meeting highlights from the AAO annual congress 2006, Las Vegas, 11-14 November
More prospective studies are needed to evaluate the role of diurnal and long-term intraocular pressure (IOP) function in glaucoma development and progression, according to Felipe A. Medeiros, MD, PhD, assistant professor of ophthalmology, University of California at San Diego, USA, speaking at the glaucoma subspecialty session.
Parameters for defining quality of vision
According to Oliver Findl, it is becoming increasingly important to use a wider variety of parameters to assess visual quality after cataract surgery in order to gain a better understanding of patient's day-to-day experiences.
Wavelight announces two IOL approvals
Wavelight has announced the receipt of two regulatory approvals for its intraocular lenses (IOLs), thus expanding its intraocular product range.
Levofloxacin should be the first choice for antibacterial prophylaxis
Levofloxacin 0.5% eye drops should be the first choice for antibacterial prophylaxis and treatment, according to Professor P. Asbell of the Mount Sinai School of Medicine, USA.
MICS has made very little impact on US and EU surgeon practice
Microincision cataract surgery (MICS), hailed to be the next big development in cataract surgery, has not had the expected impact on surgeon's practice, David Leaming revealed, whilst detailing the results of his most recent survey on cataract surgery practice in Europe and the US.
Foldable toric IOL safe and effective in high astigmatism
According to Omid Kermani from the Augenabteilung der PAN-Klinik am Neumarkt, Köln, Germany, and colleagues, the implantation of a foldable toric intraocular lens (IOL) is a safe and predictable procedure for the correction of high pre-existing corneal astigmatism in cataract surgery.
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Oculoplasty
Standardizing trauma terminology
A standardized language of trauma classification can have value for prognosis as well as description, according to Dr Dante Pieramici.
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Ophthalmology industry news
Alcon's independent directors fight back Novartis control
Novartis plans to assume complete control over Alcon Laboratories Inc. in a two-step process that some analysts and some members of Alcon?s board of directors are challenging for its fairness under Swiss and US merger laws.
Alcon to acquire Swiss Biotechnology business

The news broke at today's show that Alcon is to gain access to proprietary antibody fragment technology particularly suited to treat eye diseases with its plan to acquire ESBATech AG, a Swiss biotechnology firm.

Eyes of tomorrow
The first European Master's degree in Clinical and Surgical Ophthalmology, a prestigious international project of advanced studies for ophthalmological professionals, was presented in Lugano (Switzerland) by the European School for Advanced Studies in Ophthalmology.
Abbott acquires Visiogen for cool $400 million
$400 million in cash has secured the acquisition of Visiogen for Abbott and secured the latter a next-generation accommodating IOL technology to help presbyopia in cataract patients.
Pioneering ophthalmologist dies aged 92
Ronald Pitts Crick, the ophthalmologist who was behind the development of the operating microscope, has died aged 92.
Professor Shahina Pardhan to lead new vision research unit
Professor Shahina Pardhan has been appointed director of Anglia Ruskin University's new Vision and Eye Research Unit (VERU).
Business eyes up development of new glaucoma treatment
Ocular Therapeutics has signed non-disclosure agreements with two of the largest pharmaceutical firms in the world. The unnamed companies are interested in a new treatment approach in the largest of the ophthalmic markets.
Dr Ambati wins 2010 ARVO award
Dr Jayakrishna Ambati, professor and vice chairman of Ophthalmology and Visual Sciences at the University of Kentucky, has been chosen to receive the 2010 Cogan Award from The Association for Research in Vision and Opthalmology (ARVO).
IGA urges the public not to cut back on eye tests
The International Glaucoma Association (IGA) is urging people not to cut back on eye tests due to the recession.
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Ophthalmology product news
Product Profiles
A round up of new products
Product Profiles
A round up of new products
IQ 577 laser system now available to doctors
Iridex has commenced shipment of its IQ 577 laser systems which is designed to treat vision-threatening eye diseases such as diabetic retinopathy, age-related macular degeneration and glaucoma.
A comparison of six OCT devices
In a head-to-head comparison of six OCT devices, the Spectralis spectral domain OCT (Heidelberg Engineering) showed the lowest co-efficient of variation in a test-retest study.
Clinical trials show promise to help mydriasis during cataract surgery
Results from the Omeros Corporation for the Phase I/Phase II clinical trial of OMS302, a proprietary combination of an anti-inflammatory agent and an agent that causes pupil dilation (mydriasis) are said to be promising.
NicOx reacquires rights to PF-03187207 for glaucoma from Pfizer
NicOx S.A. has signed an agreement with Pfizer Inc to reacquire the full development and commercialization rights to PF-03187207, which has completed two phase II studies in patients with primary open angle glaucoma and ocular hypertension. As part of this agreement, Pfizer has granted NicOx the right to access and use certain proprietary Xalatan (latanoprost) data.
Ketolorac tromethamine should be available in September
Allergan Inc. expects its ketorolac tromethamine ophthalmic solution 0.45% (Acuvail) to be available in the United States in September. The preservative-free formulation of ketorolac, a nonsteroidal anti-inflammatory drug (NSAID), is indicated for the treatment of pain and inflammation after cataract surgery and received FDA approval at the end of July, the company announced.
Implant with potential to permanently treat glaucoma
OcumatRx, an early stage company that is developing a medical device that represents a new concept for the permanent treatment of patients with glaucoma, has announced the successful completion of clinical trials for their first device with favourable preliminary safety and tolerability.
Alcon discontinues development of anecortave acetate for IOP reduction
Alcon Inc. announced it has discontinued development of anecortave acetate for the reduction of IOP associated with glaucoma.
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Ophthalmology research news
Safety first: pIOL is effective for myopic astigmatism
Implantation of the Artiflex toric iris-fixated phakic IOL is effective, predictable and safe for the correction of myopic astigmatism.
Inhibiting and regressing corneal neovascularisation
Interim results from a Phase II study by Gene Signal suggest that antisense oligonucleotide GS-101 is safe and effective at inhibiting abnormal corneal new blood vessel growth.
Glaucoma related to selenium levels
The pathology of glaucoma is likely to be related to the presence and levels of selenium, according to the results of a study published in the August issue of the British Journal of Ophthalmology.
The brain predicts what moving eyes will see
A new study conducted by researchers at the University of Aberdeen, Scotland, has found that the brain predicts the consequences of eye movement even before the eyes take in a new scene.
Lowering levels of arginase may halt progression of diabetic retinopathy
High levels of the enzyme arginase contributes to vascular eye damage, and therapies to lower its levels could halt progression of diabetic retinopathy (DR), according to researchers at the Medical College of Georgia (MCG) School of Medicine, USA.
When can an eye growth transform into melanoma?
According to a report in the August issue of Archives of Ophthalmology, there are eight factors that may predict whether a choroidal nevus-a benign, flat, pigmented growth inside the eye and beneath the retina-may develop into melanoma.
Gene therapy delivers bonus results
Partial sections of vision were recently restored to a blind woman's retina through the use of gene therapy.
Researchers uncover genetic link to age-related cataracts
Researchers in Cleveland have discovered the first gene associated with the formation of age-related cataracts. EphA2 encodes an enzyme that plays a role in the repair of proteins in the lens of the eye after they become damaged and clump together, according to the investigators.
Implant with potential to permanently treat glaucoma
OcumatRx, an early stage company that is developing a medical device that represents a new concept for the permanent treatment of patients with glaucoma, has announced the successful completion of clinical trials for their first device with favourable preliminary safety and tolerability.
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Other
The what, who and why of stem cells in ophthalmology: Part 1
Ophthalmic blogger, Irv Arons writes a tell all on what stem cells are all about, who's involved, who they are collaborating with, what type of stem cells they are using and what diseases they are aimed at.
A vision for the world
Helping others to help themselves
Contact induced dry eye
Understanding the problems of contact lens induced dry eye
The ideal drop through the eyes of doctors and patients
Five steps and the criteria for success, as seen through the eyes of patients and their doctors...
OTE at the WOC
The Ophthalmology TImes Europe team is looking forward to meeting many readers and customers at the Congress and to bringing you coverage of the event and new developments emerging from it.
Standardizing trauma terminology
A standardized language of trauma classification can have value for prognosis as well as description, according to Dr Dante Pieramici.
Flying eye hospital gets new aeroplane
Orbis International, an international nonprofit humanitarian organization which operates the world"s only Flying Eye Hospital, is to upgrade from a DC-10-10 to a DC-10 Series 30 freighter airline, giving the project an extra 20 years of flying time.
Should tear dysfunction be treated with nutritional supplements?
Nutritional supplements seem to make sense as a treatment of tear dysfunction, according to Marian Macsai, MD. Dr Macsai tempered her assertion with the observation that no objective trials have been performed to support the use of nutritional supplements in patients with tear deficiency.
Minimally invasive strabismus surgery vs the limbal approach
As with all medical disciplines, the goal of every surgeon is to perform surgery that is minimally invasive, in order to reduce the risk of unwanted complications and a poor postoperative appearance, and to increase patient comfort and satisfaction.
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Paediatrics
BTA injections can treat infantile esotropia
Botulinum toxin type A (BTA) injections, with or without sodium hyaluronate (SH), are effective and feasible for the treatment of infantile esotropia.
IOP lowered with trab and combination trab
IOP is successfully reduced with both trabeculectomy and combined trabeculotomy-trabeculectomy with mitomycin C in children with glaucoma.
Maternal malnutrition is keratomalacia risk factor
Keratomalacia can be linked to lower socioeconomic status, poor maternal nutrition, and inadequate breastfeeding.
OTS is reliable in predicting paediatric cataract visual outcome
The Ocular Trauma Score (OTS) is a reliable predictor of final visual outcome in children with traumatic cataract
Anterior and posterior capsulorhexis in children
Anterior and posterior capsulorhexis in children
Paediatric ophthalmology conference programme
The Egyptian Group of Paediatric Eye Surgery (EGPES) will be hosting the 4th International Symposium of Paediatric Ophthalmology, from 4th to 6th of November 2009, in Alexandria, Egypt.
A clinical conundrum
According to the J Pediatr Ophthalmol Strabismus 2009;46:238-240 optic disc oedema is a clinical conundrum which has potential to delay diagnosis and therefore treatment of idiopathic intracranial hypertension.
Link between ROP and haemangioma in low birth-weight infants discovered
In infants with birth weights of 1250 g, haemangiomas are associated with the development of retinopathy of prematurity (ROP), according to study data published in the March 2009 issue of Pediatrics.
US introduces law protecting children's vision
The Vision Care for Kids Bill of 2009, legislation to provide vision care to children without health insurance, has been introduced in the US after being approved both by the Senate and by the House of Representatives.
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Refractive clinical
Safety first: pIOL is effective for myopic astigmatism
Implantation of the Artiflex toric iris-fixated phakic IOL is effective, predictable and safe for the correction of myopic astigmatism.
IOL power: Quo vadis?
Increasing levels of expectations of refractive results is challenging IOL power calculations, reveals Dr Oliver Findl
Optical Biometry
Dr Paul-Rolf Preussner discusses how additional optical measurements are required to improve the accuracy limits in IOL calculation
New frontiers in IOL power calculations
Following a premium IOL implantation it is now possible to maintain the target refractive error of 0.5 D but errors can still arise in the calculation of the desired IOL power. Modernizing formulae may help to reduce prediction error in IOL power calculations.
Laser capsulotomy yields predictability
An investigational femtosecond laser-assisted cataract surgery system for capsulotomy creation was evaluated in a randomized, fellow eye control study.
Debate: Best appraoch to thin cornea
Refractive specialists weigh in with views on surface ablation versus the flap-based procedure.
Be aware of potential IOL complications
The potential complications associated with implantation of phakic IOLs may give cataract surgeons a few challenges, but problems can often be averted with proper sizing and vaulting.
Review of the year 2010
A review of the year in cataract & refractive, retina and glaucoma. Shows three industry experts view on their highs of the year and the changes they've experienced as well as what the future holds for 2011
Femtosecond facilitates 'big bubble'
A new variation of femtosecond laser-assisted 'big bubble' deep anterior lamellar keratoplasty uses the laser to create an intrastromal channel serves as a pathway for the insertion of the air injection
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Refractive news
Piggyback toric IOL effective for astigmatism
Implanting a customized primary or a secondary piggyback toric IOL post-penetrating keratoplasty (PK) is effective for astigmatism, claims a paper in Eye.
Corneal astigmatism and HOAs affect IOL performance
Uncorrected corneal astigmatism and higher-order aberrations (HOAs) in pseudophakic eyes significantly affects through-focus performance of presbyopia-correcting IOLs.
CE Mark for IOL and delivery system

Abbott Medical Optics (AMO) has announced the launch and CE Mark of approval for both the Tecnis multifocal toric IOL and iTec preloaded delivery system at the ESCRS in Milan this year.

European approval for hydrophobic acrylic IOL

Bausch + Lomb introduced the enVista toric IOL for astigmatism correction for European patients at the 2012 ESCRS Congress in Milan.

Safety first: pIOL is effective for myopic astigmatism
Implantation of the Artiflex toric iris-fixated phakic IOL is effective, predictable and safe for the correction of myopic astigmatism.
Clever combo: multi-modality imaging developed by novel optics
Funding novel optics and imaging software encourages the evolution of multi-modality imaging and provides more business opportunities.
Tele visual acuity measurements are successful and reliable
A remotely operated computer-based logarithmic (logMAR) visual acuity chart is just as reliable as measurements taken by an optometrist.
Peripheral overall blur influenced by defocus and oblique astigmatism
Peripheral overall blur is largely influenced by a combination of defocus and oblique astigmatism.
Novel suturelesss scleral IOL fixation technique successful
A novel sutureless scleral IOL fixation technique is successful in patients with insufficient posterior capsule support.
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Retina clinical
Handy guide to scleral disease
JP Medical Ltd has announced the release of The Sclera and Systemic Disorders, available now.
Advanced Retinal Therapy
Advanced Retinal Therapy will be held in Vienna, Austria on 3 December 2011. At this event updates, trends and controversies in retinal tehrapy will be discussed in symposia, key-note lectures and a panel discussion session.
Ozurdex recommended for treating macular oedema

The National Institute for Health and Clinical Excellence (NICE) has recommended Ozurdex for the treatment of macular oedema caused by central retinal vein occlusion (CRVO).

Ranibizumab treatment for DME shows positive results in study
Anti-vascular endothelial growth factor agent well-tolerated, met primary efficacy endpoint.
Are we ready for ROP telemedicine?
Doctors place focus on delivery of care
Voclosporin: safe, eddective for noninfectious uveitis
Investigational agent shown to be superior to placebo in two historic multicentre studies
MIVS technique continues to evolve
Retinal surgeons refine technology, instrumentation to optimize safety and efficacy
Reducing treatment burden, cost and re-treatment
For neovascular AMD sufferers, this combination therapy may offer an alternative to continual anti-VEGF injections
Dr Patz remembered
Clinician-scientist also trained ophthalmic leaders
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Retina news
Anti-VEGF monotherapy safe and effective for SRNVM
Intravitreal anti-VEGF monotherapy is safe and effective in treatment-naïve subretinal neovascular membrane (SRNVM) secondary to macular telangiectasia (Mactel).
Drusen evolution affects photoreceptor IS/OS junction integrity
The photoreceptor inner segment/outer segment (IS/OS) junction integrity can be affected by drusen evolution.
RAAB can assess diabetes and DR

The Rapid Assessment of Avoidable Blindness (RAAB) framework can be used to assess diabetes and diabetic retinopathy (DR) but us costly and time consuming.

Ranibizumab and photodynamic therapy successful
A ranibizumab and photodynamic therapy combination can improve visual acuity and reduce exudation in polypoidal choroidal vasculopathy.
Ocriplasmin closes macular holes
Invitreal injection of ocriplasmin resolves vitremacular traction and closes macular holes.
Pegaptanib efficacious and non-toxic for ROP
Anti-VEGF therapy pegaptanib is efficacious and non-toxic for patients with retinopathy of prematurity (ROP), states a recent study.
DME treatment gets the German green light
Chronic diabetic macula oedema (DME) treatment Iluvien, developed by Alimera Sciences, has obtained marketing authorization in Germany.
IVB injections successful for mCNV
Intravitreal bevacizumab (IVB) provide sustained and effective treatment for myopic choroidal neovascularization (mCNV).
Bleb injections ward off orbital tumours
Bleb injections of subconjunctival chemotherapy lower the risk of developing orbital tumours in patients with retinoblastoma.
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Supplements
Products in Practice 2013
Real world experience of leading ophthalmic products - issue 2
Intracameral antibiotic prophylaxis
New product approved to prevent postoperative endophthalmitis following cataract surgery
Products in Practice 2012
Products in Practice supplement for 2012
Individualized therapy — The modern standard in wet AMD care
Novartis sponsored a symposium at the COPHy congress in 2012 exploring the current treatment issues surrounding wet AMD. This supplement reveals the highlights of the meeting.
SeeingMilan
OTEurope's guide to Milan for the XXX ESCRS Congress
Meibomian gland dysfunction
From theory to daily ophthalmic practice
Meibomian gland dysfunction, from theory to daily ophthalmic practice
SET: A Diagnostic & Treatment Strategy for Dry Eye Associated With MGD
An expert panel convened to explore the multifactorial condition, MGD, and assess the science that may yield symptom relief.
A Decade of Selective Laser Trabeculoplasty
Examining the role of SLT in the glaucoma treatment arsenal
Seeing clearly
Balancing risk in ophthalmic prescribing for wet AMD
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VISION 2020
And the Nobel prize for vision award goes to?
This year's highly prestigious Champalimaud Vision Award is shared between two worthy winners for their ground-breaking research in neuroscience and how the brain contructs images.
Positive action absolutely imperative
World Sight Day is an international day of awareness to focus attention on the global issue of avoidable blindness and visual impairment. This year the theme is Gender and Eye Health – equal access to care
A pilot intervention
The background to the Egyptian Menia study
Committed to ophthalmology
Changes of culture and strategy at Pfizer are good news for ophthalmology
A joint effort to give everyone the right to sight
Forty five millon people are blind worldwide, yet 80% of blindness is avoidable
Helping to influence community health in Pakistan
A pioneering model of community health
Reaching women in Egypt
Leadership and evidence-based approaches to alleviate the burden of blindness
A Kenyan doctor's perspective
A Kenyan doctor's perspective
Seeing is Believing means business
The Seeing is Believing initiative at Stardard Chartered Bank
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Survey
Which clear corneal incision technique do you use the most?
Three-plane incision
Single-plane angled manual incision
Three-plane incision
40%
Single-plane angled manual incision
60%
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