Based on our experience, we have been able to develop some real staging-based guidelines for the therapeutic treatment of
keratoconus and, in our opinion, corneal collagen cross-linking is mainly effective in the first and second stage of the disease.
We believe that an early keratoconus diagnosis is necessary in order to optimize cross-linking efficacy, delay keratoconus
progression and reduce the need for corneal transplants. We truly believe that this new equipment represents one of the most
advanced technologies available for the cross-linking technique and, as we assimilate further patient data, no doubt more
widespread use will follow.
Our thanks go to Luciano Sassano (C.S.O., Italy) and Riccardo Nicoletti (C.S.O., Italy) for all of their technical support.
Aldo Caporossi MD, FRCS, Cosimo Mazzotta MD, PhD & Stefano Baiocchi MD, PhD work at Siena University, Siena, Italy. Dr Caporossi may be reached by E-mail: email@example.com
Aldo Caporossi MD, FRCS
Cosimo Mazzotta MD, PhD
Stefano Baiocchi MD, PhD
1. G. Wollensak, E. Spoerl, T. Seiler. Am. J. Ophthalmol., 2003;135:620-627.
2. A. Caporossi, et al. J. Cataract Refract. Surg. 2006;32:837-845.
3. C. Mazzotta, et al. Eur. J. Ophthalmol. 2006;16(4):530-535.
4. C. Mazzotta, et al. Cornea 2007;26(4):390-397.
5. R. Mencucci, C. Mazzotta et al. J. Cataract Refract. Surg. 2007;33(6):1005-8.
6. A. Caporossi, S. Baiocchi, C. Mazzotta. La Voce A.I.C.C.E.R., 2006;4.