Take a look at what happened in the Retina field in 2007 and what exciting developments are round the corner in 2008.

Randomized data from a large cohort of women with cardiovascular disease or at a high risk of it indicate that seven years of daily supplementation with folic acid, vitamin B6, and vitamin B12 may reduce the risk of age-related macular degeneration (AMD), according to William G. Christen, ScD, PhD.

The field of age-related macular degeneration (AMD) research continues to experience exciting and fascinating times, with the recent launches of new therapeutics and several others on the horizon giving hope to more patients than ever before. Coupled with advances in imaging and diagnostic technology, retina specialists now face AMD with fresh optimism — treatments and technologies are available that will help them to delay or maybe even halt disease progression in their patients.

A UK team reports how they achieved significant reductions in macular thickness by using intravitreal bevacizumab.

The National Institute for Health and Clinical Excellence (NICE) in England produced its first Appraisal Consultation Document (ACD) regarding the use of anti-vascular endothelial growth factor (anti-VEGF) drugs for the treatment of wet age-related macular degeneration (AMD) recently. Essentially, the document recommended that the new anti-VEGF inhibitor Lucentis (ranibizumab; Novartis Ophthalmics) may be used only to treat predominantly classic subfoveal choroidal neovascularization (CNV) which shows evidence of progression in the second affected eye, provided the visual acuity is between 6/12 and 6/96.1 After considering feedback from formal consultees, the Appraisal Committee will prepare a Final Assessment Document (FAD) for submission to NICE who will then issue guidance.

Pilot study, which examines the benefits of combining photodynamic therapy (PDT) with bevacizumab (Avastin) in AMD patients, yields promising results.

The introduction of anti-VEGF therapy has revolutionized the treatment of neovascular age-related macular degeneration (AMD); the main cause of blindness in the industrialized world. Large numbers of previously untreatable patients will now be eligible for treatment which, in itself, represents an overwhelming challenge to healthcare providers. Discussion and careful planning is needed to ensure that the manpower and funds are in place to deal with this new era in ophthalmic care.

The economical cost [of blindness] to society is extremely significant, with the annual financial cost estimated at €1.5 billion in France, €3.3 billion in Germany, €0.7 billion in Spain and €1 billion in the UK

Last year, Philip Rosenfeld of the Bascom Palmer Eye Institute in Miami, USA, announced some findings that made the ophthalmology community stand to attention. He claimed that intravitreal administration of the cancer agent, Avastin (bevacizumab), in wet age-related macular degeneration (AMD) patients yielded very positive results. Since then, industry journals have been inundated with reports of the benefits of this agent in an ophthalmic setting.