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Thursday, 28 August 2014
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Phase I trial of plasma inhibitor for DME started
August 28, 2014
KalVista Pharmaceuticals has begun a Phase I trial of its plasma kallikrein inhibitor KVD001 for the treatment of diabetic macular oedema (DME).
DNA test accurately diagnoses rare diseases
August 27, 2014
Advanced DNA testing for congenital cataracts can quickly and accurately diagnose a number of rare diseases marked by childhood blindness, according to a study recently published online.
Age-related HS changes have implications for AMD
August 22, 2014
Researchers examining age-related changes in heparan sulphate (HS) quantity and composition in human Bruch's membrane (BrM) have discovered that the quantity greatly decreases with age, resulting in fewer binding sites for complement factor H (CFH) and affecting the ability of the 402H variant of CFH to bind BrM.
iPad games effective against amblyopia
August 21, 2014
A home-based treatment of amblyopia that incorporated an iPad quickly resulted in improved visual acuity (VA) in the children in whom it was tested, and VA remained stable for at least 3 months after the treatment ended, according to research published online.
RNFL loss tied to slower reaction times
August 20, 2014
Glaucomatous structural damage may affect an individual's ability to divide attention when performing daily tasks such as driving, according to research recently published online.
June 2014
Cover feature
Outlook for integrin peptide therapy
By: Peter K. Kaiser, MD
ALG-1001 is the first of a new class of drugs, integrin peptide therapy, now going through clinical trials for patients with age-related macular degeneration, diabetic macular oedema and vitreomacular traction.
Fighting AMD: the power of nutrition
With a greater understanding of how ocular nutrition affects sight, ophthalmologists need to encourage healthy diets with nutrients and antioxidants essential for healthy vision.
Anti-VEGF use in infants
Numerous trials assessing the efficacy and safety of anti-VEGFs in adults exist, however, the clinical evidence and basic science research of anti-VEGF use in infants is lacking, according to Dr Drenser. Here, she discusses what is required from future studies to justify the use of anti-VEGFs in young patients.
Dry AMD: A new hope
Dry age-related macular degeneration (AMD) is the most common cause of vision loss in developed countries. Although anti-VEGFs can be used to improve the quality of life for patients with the wet form of the disease there is still not much to offer dry AMD patients. In this article, Dr Georgiou highlights the results of his recent study looking at the value of higher doses of omega-3 fatty acids for this group of patients.
Cataract and Refractive
Weather impacts on the outcome of LASIK
Environmental factors have been discussed as possible triggers for diseases. Recently, the authors analysed the impact of seasonality and distinct meteorological parameters on refractive and visual outcome of LASIK in myopic eyes, here, they present the highlight of this study.
How a flapless procedure provides improved optical quality
By: Cheryl Guttman Krader, Professor Dan Z. Reinstein
Results of a study comparing matched groups of eyes undergoing myopic correction by small-incision lenticule extraction (SMILE) or LASIK show that the optical quality was better and the cornea retained higher tensile strength after the flapless SMILE procedure.
Optimization of toric IOL performance
By: Dr Oliver Findl
In this article, the authors discuss their study that was aimed at evaluating the rotational stability and patient visual quality of a toric IOL with a novel haptic design.
Pupil size doesn't matter, study says
By: Dr Steven C. Schallhorn
In this article, Dr Schallhorn reveals the results of a large case series that provides evidence that there is no need to reject candidates for LASIK on the basis of pupil size or to increase the treatment zone size for such patients.
Retina
New blade design for pars plana vitrectomy: A quantum leap
In this article, the authors present the highlights of their research into a new blade design for pars plana vitrectomy.
Spontaneous closure of FTMH after vitrectomy for VMT
In this article, the authors summarize a recently published case study of a macular hole formation and its spontaneous closure after vitrectomy.
Glaucoma
Changes in the ocular surface after glaucoma therapy
Prof. Iester describes his recent study investigating whether the addition of a tear substitute would protect exposed corneal epithelial cells from damage.
Additional editorial
Managing oxygen levels in preterm infants
Findings from recent clinical trials are providing some guidance on oxygen management in preterm infants.
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May 2014
Cover feature
Warming up to the 'ICE' procedure
By: Steven R. Sarkisian Jr., MD
The combination of microinvasive glaucoma surgeries with cataract surgery may address a patient's cataract and glaucoma in one procedure.
Sutureless trabeculectomy
By: Dr Mohammad Arish, DO, FRCS, Dr Hoda Khallaghi
In this article, the authors describe their novel technique for penetrative trabeculectomy in primary open-angle glaucoma patients, called sutureless trabeculectomy.
Glaucoma surgery with CLASS
By: Professor Ehud Assia, MD, Dr Shlomo Melamed
Carbon dioxide laser assisted sclerectomy surgery (CLASS) is being used as an effective and safe, minimally invasive treatment for glaucoma. In this article, two surgeons at the forefront of research, development and implementation of this approach discuss this surgical option and its benefits for the ophthalmic market.
Cataract and Refractive
Multi-component IOL
By: Dimitra M. Portaliou
In this article, Dr Portaliou discusses a new multi-component adjustable lens that may be the answer paediatric ophthalmologists have been waiting for.
Multifocal intraocular lens implantation in children
By: Professor Jagat Ram, MS, Dr Aniruddha Agarwal, MS, Dr Jaidrath Kumar, MS, Dr Adit Gupta, MS
In children, implantation of a multifocal IOL remains a topic of debate. With lacking evidence on post surgery outcomes and no head-to-head comparison of multifocal IOLs in children, this issue remains to be clarified. Therefore, the authors of this article were prompted to perform research in this area to address a number of concerns among paediatric ophthalmologists.
Calculating IOL power for children
By: Dr Rupal H. Trivedi, MSCR
Determining the optimal IOL power for children is as much an art as a science.
Retina
Drug slows diabetic retinopathy, but delays may limit its effect
By: Lynda Charters, Dr Michael S. Ip
The natural history of diabetic retinopathy is modified by long-term treatment with intravitreal ranibizumab, reports one ophthalmologist.
Glaucoma
Advances in automated alternation flicker
By: Elizabeth D. Marlow, BA, Dr Nathan M. Radcliffe
The authors have sought to expand the concept of automated alternation flicker to improve detection of glaucomatous optic neuropathy and highlight their findings in this article.
Preservatives in glaucoma medications
By: Professor Christophe Baudouin
Preservatives are an important component of topical multidose glaucoma medications. However, many glaucoma patients have symptoms of ocular surface disease (OSD), which can affect quality of life, treatment adherence and surgical outcomes. In this article, Prof. Baudouin offers straightforward steps to assess OSD and identify the patients most at risk.
Additional editorial
Longitudinal versus torsional phaco
By: Dr Wilson Takashi Hida, PhD
Several new refractive surgical platforms have been introduced recently and many ophthalmologists are discovering they find the new technologies to be more efficient and produce better results.
General
Meeting preview: Vision UK 2014
This year, the Vision UK 2014 conference was to be held on Thursday 12 June at the Queen Elizabeth II conference centre in London, UK. Attendees can look forward to key opinion leaders discussing the UK Vision Strategy and emphasizing the initiatives that need to be implemented across the UK.
Prevalence of 'floppy eyelid' syndrome among employed people
By: Dr Milena Sredkova
In this article, the author discusses a recent study determining the frequency of 'Floppy eyelid' syndrome among patients of an active working age range.
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A round-up of the latest ophthalmic products
Ophthalmology Times Europe is the independent source for current developments and best practices in European Ophthalmology. It is the balanced and unbiased forum for ophthalmologists to communicate practical experience, clinical knowledge, discoveries and applications, thereby promoting improvements in medical medical practice and patient health.
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